Water intoxication during carbamazepine treatment.

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Water intoxication during carbamazepine treatment.

Carbamazepine has recently been shown to have a vasopressin-like action and, like chlorpropamnide, to be effective in controlling polyuria in patients with diabetes insipidus (Hartman, 1972; Uhlich et al., 1972). In the case reported here carbamazepine, which was being given to a patient suffering from depression and psychogenic polydipsia, induced inappropriate secretion of antidiuretic hormon...

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Water intoxication in epileptic patients receiving carbamazepine.

Plasma sodium and osmolality were determined in 80 adult epileptic patients receiving chronic treatment with carbamazepine and in 50 control patients treated with other anticonvulsant drugs. Mean plasma osmolality was significantly lower in the carbamazepine-treated patients but mean plasma sodium did not differ in the two groups. Hyponatraemia was found in five of the carbamazine-treated patie...

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High-flux haemodialysis treatment as treatment for carbamazepine intoxication.

Acute severe intoxication with carbamazepine is associated with seizures, coma and respiratory depression. Traditionally, charcoal haemoperfusion is used to remove the drug. We present a case of carbamazepine intoxication, successfully treated with three hours of high-flux haemodialysis. Thus, haemodialysis using high-flux membranes is a feasible and effective therapeutic option for carbamazepi...

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Treatment of Severe Carbamazepine Intoxication with Intravenous Lipid Emulsion Therapy

Carbamazepine (CBZ) is a widely prescribed anticonvulsant agent. It is used in treatment of epilepsy including general tonic-clonic, simple partial and complex partial seizures, neuropathicpains, especially in trigeminalneuralgia, central diabetes insipidus, attention-deficit and hyperactivity disorders and bipolar disorders. CBZ overdose is usually associated with cardiac, neurologic and respi...

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Pulmonary oedema during treatment of acute water intoxication.

Acute water intoxication with deepening coma and uncontrolled epileptiform seizures in a 25-year-old previously fit male schizophrenic was treated with hypertonic (2 N) saline and a 20% mannitol solution. This improved his neurological state but precipitated severe pulmonary oedema. Intravenous frusemide increased his urinary output sufficiently to clear the pulmonary oedema. In acute water int...

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ژورنال

عنوان ژورنال: BMJ

سال: 1973

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.3.5878.479